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本文对服用醋酸棉酚停药恢复生精后所生子代30例及相应的对照组进行了外周血淋巴细胞染色体的观察。实验组的父代每日口服醋酸棉酚20mg,服至起效(一般服药后60～90天以每毫升精液中精子数在400万以下者定为起效指标)。起效后改为维持量,每周40mg。父代平均服药的时间为440天,平均服药总量为3382.34mg。停药后至受孕,时间平均为18个月。结果提示:30例服醋酸棉酚的子代与相应对照组儿童在染色体断裂、裂隙及SCE 均未见明显差异。
In this paper, gossypol acetate withdrawal and recovery of spermatogenesis after birth, 30 cases of progeny and the corresponding control group were observed in peripheral blood lymphocytes. The experimental group’s father daily oral administration of gossypol acetate 20mg, serving until onset (usually 60 to 90 days after taking sperm per ml of sperm in less than 4 million as the onset index). After the effect changed to maintain the amount of 40mg per week. The average father’s medication time is 440 days, the average medication was 3382.34mg. After stopping to pregnancy, the average time was 18 months. The results suggest that there is no significant difference in the chromosomal rupture, cleft and SCE among 30 offspring taking gossypol acetate and the corresponding control group.