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目的 :探讨胆囊癌中粘附分子CD4 4v6、基质金属蛋白酶 2 (matrixmetalloproteinase 2 ,MMP 2 )的表达及临床意义 ,以及二者之间的关系。方法 :采用免疫组织化学方法检测 4 2例胆囊癌、10例慢性结石性胆囊炎组织中CD4 4v6和MMP 2的表达。结果 :①CD4 4v6阳性表达率在胆囊癌组为 6 4 .3% (2 7/ 4 2 ) ,明显高于慢性结石性胆囊炎组 (0 / 10 ) (P <0 .0 0 5 ) ;CD4 4v6表达与胆囊癌的组织类型、病理分级以及转移相关 (P <0 .0 5 ) ;CD4 4v6阳性的胆囊癌病人预后较差。②MMP 2在胆囊癌组织中表达率为 6 1.9% ,明显高于慢性结石性胆囊炎组 (10 % ,P <0 .0 0 5 ) ;MMP 2的表达与胆囊癌细胞的分化、转移和预后有关 (P <0 .0 5 ) ,与组织类型无关。③CD4 4v6和MMP 2在胆囊癌组织中表达呈正相关 (P <0 .0 0 5 )。结论 :CD4 4v6和MMP 2的表达与胆囊癌分化、转移、预后有关 ,在胆囊癌细胞的侵袭和转移中起重要作用。联合检测有利于评估胆囊癌的生物学行为和判断预后。
Objective: To investigate the expression and clinical significance of adhesion molecule CD4 4v6 and matrix metalloproteinase 2 (MMP 2) in gallbladder carcinoma and the relationship between the two. Methods: The expressions of CD4 4v6 and MMP 2 in 42 cases of gallbladder carcinoma and 10 cases of chronic calculus cholecystitis were detected by immunohistochemistry. Results: ① The positive rate of CD4 4v6 in gallbladder carcinoma group was 64.3% (27/42), which was significantly higher than that in chronic stone cholecystitis group (0/10) (P <0.05). CD4 The expression of 4v6 was correlated with the histological type, pathological grade and metastasis of gallbladder carcinoma (P <0.05). The prognosis of patients with CD4 4v6-positive gallbladder carcinoma was poor. ②MMP 2 expression in gallbladder cancer tissue was 6 1.9%, significantly higher than the group of chronic stone cholecystitis (10%, P <0.05); MMP 2 expression and gallbladder cancer cell differentiation, metastasis and prognosis (P <0.05), regardless of the type of tissue. ③CD4 4v6 and MMP 2 expression in gallbladder cancer was positively correlated (P <0.05). Conclusion: The expression of CD4 4v6 and MMP 2 are related to the differentiation, metastasis and prognosis of gallbladder carcinoma and play an important role in the invasion and metastasis of gallbladder carcinoma. Joint detection is conducive to assess the biological behavior of gallbladder cancer and determine the prognosis.