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A new vitamin B_(12) coenzyme analogue 2’,5’-dideoxyuridinyicobalamin and two other 2’,5’-dideoxynucleosidecobalamins of adenosyl-and thymidyl-were synthesized by an improved method, It consists in direct tosylation of the nucleoside and followed by reaction with reduced hydroxocobalamin(vitamin B_(12)). All the 2’-deozynucleoside derivatives were characterized by UV-Vis and ~1HNMR spectroscopy.