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用人角膜给猕猴移植,共7只。第2、3、6号猴供片直径是7.5mm,植床直径是7.0mm;第1、4、5、7号猴的供片直径力6.2mm,植床直径为6.0mm;结果:第2、3只猴植片透明达1年以上,第6只猴已透明20个月,现仍在观察中,第1只猴17天死亡,死前植片透明,第4、5、6只猴,植片透明4.5～8个月,小植片比大植片透明时间较长。实验猴№2术后8个月时,植片内皮细胞的密度为2570个/mm~2,术后13个月时为1800个/mm~2,植片内皮的丢失率超过生理下降速度。扫描电镜检查证实,人角膜内皮可以在猴眼上生存一个相当长的时间。免疫排斥反应,早期和轻型者,可用激素控制;后期和新生血管明显者,激素难以奏效。这一实验模型的建立,为今后研究异种角膜移植提供了有用的材料。
The cornea was used to transplant macaques, a total of seven. The number of monkey 2,3,6 for the donor diameter is 7.5mm, the diameter of the implantation bed is 7.0mm; No. 1,4,5,7 monkey feeding force diameter 6.2mm, the diameter of the bed 6.0mm; Results: 2 and 3 monkeys transparent for more than 1 year, the first 6 monkeys have been transparent for 20 months, is still under observation, the first monkey died on the 17th day, dead before the plant transparent, 4,5,6 Monkey, transparent 4.5 to 8 months of planting, transplanted plantlets longer than transparent. At 8 months after operation №2, the density of implanted endothelial cells was 2570 cells / mm2, and at 1800 hours / mm2 at 13 months after operation, the rate of loss of endothelial cells in the explants exceeded the physiological decline rate. Scanning electron microscopy confirmed that human corneal endothelium can survive in the monkey eye for a long time. Immune rejection, early and light, can be controlled by hormones; late and neovascular obvious, hormones difficult to work. The establishment of this experimental model for the future study of xenograft provides a useful material.