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目的：探讨新生儿重症监护病房住院患儿医院感染的影响因素及其干预措施。方法选取2013到4月至2014年4月本院新生儿重症监护病房收治的住院患儿100例，随机分为对照组与研究组，各50例，对照组患儿予以常规干预措施，研究组患儿予以针对性干预措施，对比两组患儿的医院感染情况，分析患儿医院感染的影响因素。结果两组患儿在医院感染情况方面，对照组患儿医院感染发生率为36.0%，研究组患儿医院感染发生率为8.0%，研究组患儿的有效率显著低于对照组，差异有统计学意义( P<0.05)；经过多因素Lo-gistic回归分析可知：基础疾病(项)、抗菌药种类(种)、是否早产儿、是否机械通气均为患儿医院感染的影响因素( P<0.05)。结论新生儿重症监护病房住院患儿医院感染的影响因素较多，发生率也比较高，相关部门应该针对性的采取医院感染护理以及管理措施，降低医院感染的发生率。“,”Objective To explore the influencing factors and intervention measures for the hospital infection of the ICU hospitalized neonate. Methods A total of 100 neonates with intensive disease were selected and were randomly divided into control group and study group, with 50 cases in each group. The neonate in the control group were given conventional intervention measures, while the neonate in the study group were given targeted intervention. The infection of the neonate of the two groups were compared and the influencing factors of infection were analyzed. Results In terms of the hospital infection, the recurrance rate of the control group′s neonate was 36. 0%, while the study group was 8. 0%, the effective rate of the study group was significantly lower than that of the control group, the difference was sta-tistically significant ( P<0. 05 ); according to the multivariate Logistic Regression analysis, the influencing factors for the hospital infection of the hospitalized child include:underlying disease ( nape) , the type of antibacterial drug ( spe-cies) , being premature infant or not and mechanical ventilation or not ( P<0. 05 ) . Conclusion There are a great number of influencing factors for the ICU neonate and the hospital infection of the hospitalized child, and the incidence rate is relatively high. Therefore, the relevant departments should provide hospital infection nursing and take manage-ment measures targetedly, so as to reduce the incidence rate of the hospital infection.