人卵巢未成熟卵母细胞体外成熟及受精的研究

• 作 者: 刘军 杨京京 刘斌 高荣莲
• 机 构: 北京医科大学组织学与胚胎学系,北京医科大学组织学与胚胎学系,北京医科大学组织学与胚胎学系,第三临床医学院妇产科 北京100083
• 出 处: 科学通报
• 发表日期: 1995年17期
• 关键词: 未成熟卵母细胞 人卵巢 体外受精 超排卵 卵巢发育不全 fertilization 成熟卵子 embryo 反应者 卵泡液

体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET,简称IVF)技术已经建立.但是,目前IVF技术主要适用于能够进行超排卵的病人,对于绝经期过早或卵巢发育不全及生殖障碍的妇女、经过放疗或化疗后的年轻妇女、对超排卵治疗长期无反应者、X-连锁遗传病及常染色体显性遗传病都需要卵子的捐献.成熟卵子的捐献来源还十分困难.学者们设想如果能把人未成熟卵母细胞在体外培养至成熟状态从而建立卵子库,将具

In vitro fertilization and embryo transfer (IVF-ET, IVF for short) technology has been established, however, the current IVF technology is mainly applicable to patients who are able to undergo superovulation, with premenopausal symptoms or ovarian hypoplasia and reproductive Obstacles to women, young women after radiotherapy or chemotherapy, long-term non-responders to superovulation, X-linked genetic disease and autosomal dominant disease require the donation of eggs, and it is still very difficult to source the mature eggs. We envisaged that if we can immature human oocytes cultured in vitro to mature state to establish an egg pool, will have