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目的观察矾冰纳米乳治疗浅Ⅱ度烧伤的临床疗效及安全性。方法将120例患者随机分为治疗组和对照组,分别用矾冰纳米乳和矾冰液治疗10天,评价综合疗效、主症起效时间、消失时间、即刻镇痛疗效、创面动态愈合率、创面完全愈合时间及安全性。结果治疗组愈显率为90%,总有效率为100%;对照组分别为81.7%、95%,两者比较差异无统计学意义(P>0.05),减轻局部红肿及镇痛效果治疗组优于对照组(P<0.05或P<0.01),创面动态愈合率和完全愈合时间比较治疗组优于对照组(P<0.01)。两组治疗前后血、尿、大便常规,肝、肾功能,心电图各项指标差异无统计学意义(P>0.05)。结论两种药物治疗浅Ⅱ度烧伤均具有良好疗效,但矾冰纳米乳在改善主要症状和镇痛、促进创面愈合方面优于矾冰液。
Objective To observe the clinical efficacy and safety of alum ice nanoemulsion in the treatment of superficial second degree burn. Methods One hundred and twenty patients were randomly divided into treatment group and control group, treated with alum ice nanoemulsion and alum fluid for 10 days respectively. The comprehensive curative effect, the onset time of main symptoms, the disappearance time, immediate analgesic efficacy, dynamic wound healing rate , Wound healing time and safety. Results In the treatment group, the cure rate was 90% and the total effective rate was 100%. The control group was 81.7% and 95% respectively. There was no significant difference between the two groups (P> 0.05) Compared with the control group (P <0.05 or P <0.01), the dynamic wound healing rate and the complete healing time were better in the treatment group than in the control group (P <0.01). Before and after treatment, blood, urine, stool, liver, kidney function, ECG showed no significant difference (P> 0.05). Conclusion Both drugs have good curative effect on superficial second degree burn, but alum ice nanoemulsion is better than alum ice liquid in improving the main symptoms and analgesia and promoting wound healing.