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目的了解陕西省铜川市健康人群百日咳、白喉、破伤风(百白破)抗体水平,为有效控制百白破提供参考依据。方法采用分层多级抽样的方法,在铜川市4区(县)随机抽取<1岁、1～2岁、3～4岁、5～6岁、7～14岁、15～19岁、≥20岁健康人群368人,用酶联免疫吸附试验测定百日咳、白喉、破伤风IgG抗体。结果 2011年铜川市健康人群百日咳抗体阳性率为38.04%,抗体几何平均浓度(GMC)为54.56 U/ml;白喉抗体阳性率94.02%,安全保护率60.87%,GMC为1.61 IU/ml;破伤风抗体保护率55.71%,GMC为2.70 IU/ml。结论铜川市健康人群百日咳IgG抗体阳性率低,7岁以上人群白喉及破伤风抗体保护率较低。预测铜川市近年不会发生白喉及新生儿破伤风疫情,但存在百日咳流行的隐患。故今后应通过加强百日咳的诊断及时规范管理病例,避免传播,还应按免疫程序及时加强免疫,并建议对大年龄组人群接种低白喉、破伤风联合疫苗含量的疫苗。
Objective To understand the levels of pertussis, diphtheria and tetanus (Baibabuai) antibody in healthy population in Tongchuan, Shaanxi Province, and to provide a reference for the effective control of. Methods A stratified multistage sampling method was used to randomly select patients aged less than 1 year, 1 to 2 years, 3 to 4 years, 5 to 6 years, 7 to 14 years, 15 to 19 years and 4 years or more in Tongchuan 368 healthy people aged 20 years were tested for pertussis, diphtheria and tetanus IgG antibody by enzyme-linked immunosorbent assay. Results The positive rate of pertussis antibody in healthy population in Tongchuan City in 2011 was 38.04%, the mean geometric mean antibody concentration (GMC) was 54.56 U / ml; the positive rate of diphtheria antibody was 94.02%, the safety protection rate was 60.87% and the GMC was 1.61 IU / ml; Antibody protection rate was 55.71%, GMC was 2.70 IU / ml. Conclusion The prevalence of pertussis IgG in healthy people in Tongchuan is low, and the protection rate of diphtheria and tetanus in people over 7 years old is low. In recent years, the occurrence of diphtheria and neonatal tetanus does not occur in Tongchuan City, but the prevalence of pertussis is still hidden. Therefore, in the future, the diagnosis of pertussis should promptly standardize the management of cases and avoid transmission. In the meantime, vaccination should be strengthened in time according to the immunization schedule. Vaccination against low-diphtheria and tetanus combined vaccines should be recommended to older age groups.