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目的：：建立一测多评( QAMS)法测定六味五灵片中连翘苷、五味子醇甲、五味子酯甲、五味子甲素、五味子乙素和五味子丙素等6种有效成分的含量，验证该方法在制剂中应用的准确性和可行性。方法：采用HPCL法，在230nm检测波长下建立五味子甲素与五味子乙素、五味子丙素、五味子酯甲、五味子醇甲和连翘苷的相对校正因子( f)，计算六味五灵片中各成分的含量，实现一测多评。同时采用外标法测定，并计算QAMS法含量计算结果( Wf )和外标法含量测定结果( Ws )的相对误差，验证一测多评法的准确性，并对其重现性进行考察。结果：建立用于测定六味五灵片中6种成分含量的QAMS法，并对10批制剂中六味五灵片的指标成分进行测定，其计算值与测定值的差异较小( RSD<5%)。结论：QAMS法用于测六味五灵片6种有效成分的含量，方法简单、有效、结果准确。 QAMS法测六味五灵片的质量评价模式得到了验证，可用于六味五灵片的质量控制，并为后续的一测多评的研究提供参考价值。“,”Objective:To establish a quantitative analysis of multi-components by single marker ( QAMS) method for the determi-nation of six components ( phillyrin, schizandrol, schisandra ester, deoxyschizandrin, schisandrin B and schisandrin C ) in Liuwei Wuling tablets,and verify the accuracy and feasibility of the method applied in the preparation. Methods:The relative correction factor ( f) of schisandrin B, schisandrin C, schisandra ester, schizandrol, phillyrin and deoxyschizandrin was detected by HPLC at the detec-tion wavelength of 230nm, and the contents of the components in Liuwei Wuling tablets were calculated to achieve the multi evaluation. Meanwhile, the contents of the six components were analyzed by an external standard method and the relative error between the calcula-tion of QAMS method ( Wf ) and the result of the external standard method ( Ws ) was calculated to verify the accuracy of QAMS. The reproducibility of the method was also investigated. Results:The QAMS method was established to determine the contents of 6 compo-nents in Liuwei Wuling tablets, and the components in 10 batches of Liuwei Wuling tablets were determined. The differences between the calculated values and the measured values were small ( RSD < 5%) . Conclusion:The QAMS method is simple, effective and ac-curate in determining the contents of 6 effective components in Liuwei Wuling tablets. The quality evaluation model of QAMS for Liuwei Wuling tablets is validated, which can be used for the quality control of Liuwei Wuling tablets and provide reference for the further study.