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表皮生长因子(EGF),是1962年Cohen从小鼠颌下腺提取的物质,认为与人的正常细胞和癌细胞的分化、增殖密切相关。作者对口腔粘膜创伤治愈过程中EGFR出现的形式进行了研究。 取3周龄雄性鼠50只,将其中45只舌尖切除2mm,然后分别于1,3,5,7,9,11,13,15及30d,各处死5只。常规组织切片,HE和免疫组化染色,镜检。 组织学检查结果为创伤后第1d,舌尖创面均未见闭锁,创面被覆坏死组织,其下中性白细胞高度浸润和毛细血管增生,肉芽形成。第3,5d,创面缩小。但未见闭锁。7d后创面完全由上皮被覆。9～15d所见与第7
Epidermal growth factor (EGF), a substance Cohen extracted from mouse submandibular gland in 1962, is believed to be closely related to the differentiation and proliferation of normal human and cancer cells. The authors examined the appearance of EGFR during the healing of oral mucosal wounds. Fifty male 3-week-old mice were sacrificed and 45 of them were resected 2mm, then 5 rats were killed at 1, 3, 5, 7, 9, 11, 13, 15 and 30 days respectively. Routine histological sections, HE and immunohistochemical staining, microscopic examination. Histological examination results showed that on the 1st day after trauma, no occlusion was found on the tongue surface. The wounds were covered with necrotic tissue, with a high degree of neutrophil infiltration and capillary hyperplasia and granulation formation. On the 3rd and 5th day, the wound was narrowed. But no lockout. The wounds were completely covered by epithelium after 7 days. 9 ~ 15d seen with the first 7