论文部分内容阅读
目的探讨常规(CF)、三维适形(3DCRT)和调强(IMRT)放疗治疗食管癌的近期疗效及放疗反应。方法选择2006年9月～2008年1月我院收治的食管癌患者中行单纯放疗的患者共149例,其中采用常规放疗68例(CF组),三维适形放疗45例(3DCRT组),调强放疗36例(IMRT组),均采用6MVX线照射,2.0Gy/次,5次/周,总剂量为60～66Gy、分30～33次、40～45d完成,比较3组的近期疗效及放疗反应。结果 CF组、3DCRT组和IMRT组有效率分别为70.6%、91.1%和91.7%。CF组与3DCRT组和IMRT组有效率差异有统计学意义(P<0.05～0.01)。各临床分期近期疗效差异有统计学意义(P<0.01)。3组1年局部控制率分别为55.4%、70.5%和69.4%;3组2年局部控制率分别为30.8%、50.0%和58.3%;3组1年生存率分别为75.4%、84.1%和83.3%;3组2年生存率分别为33.8%、54.6%和58.3%。3DCRT组+IMRT组放射性食管炎发生率较CF组高(P<0.05),放射性肺炎发生率CF组较IMRT组+3DCRT组高(P<0.05),骨髓抑制反应3DCRT组+IMRT组较CF组轻(P<0.05)。结论 3DCRT和IMRT方法能提高食管癌的临床疗效,放射反应均可耐受。
Objective To investigate the short-term efficacy and radiotherapy response of conventional (CF), three-dimensional conformal (3DCRT) and IMRT radiosurgery for esophageal cancer. METHODS: A total of 149 patients with esophageal cancer admitted to our hospital from September 2006 to January 2008 were treated with conventional radiotherapy in 68 cases (CF group) and three-dimensional conformal radiotherapy (3DCRT group) The patients in IMRT group were treated with 6MVX radiation, 2.0Gy / time, 5 times / week, total dose was 60-66Gy, 30-33 times, 40-45 days. The short-term curative effect and Radiotherapy response. Results The effective rates of CF group, 3DCRT group and IMRT group were 70.6%, 91.1% and 91.7% respectively. CF group and 3DCRT group and IMRT group, the effective rate difference was statistically significant (P <0.05 ~ 0.01). The recent clinical staging differences were statistically significant (P <0.01). The 1-year local control rates in 3 groups were 55.4%, 70.5% and 69.4% respectively. The 2-year local control rates in 3 groups were 30.8%, 50.0% and 58.3% respectively. The 3-year 1-year survival rates were 75.4%, 84.1% 83.3%; 3-year 2-year survival rates were 33.8%, 54.6% and 58.3%. The incidence of radiation esophagitis in 3DCRT group and IMRT group was higher than that in CF group (P <0.05). The incidence of radiation pneumonitis in CF group was higher than that in IMRT group and 3DCRT group (P <0.05) Light (P <0.05). Conclusion The 3DCRT and IMRT methods can improve the clinical efficacy of esophageal cancer and the radiation response can be tolerated.