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氢氧化铝对人体无害,是FDA 唯一认可的疫苗辅助剂,作用机理尚未十分清楚,曾简单地认为是吸附作用,但已知表面积、表面电荷和形态等性质无疑是影响其作用的重要因素。本文综述这方面的有关资料。pH4以下的铝盐溶液开始时基本上以Al(OH_2)_(?)~(+3)存在,以后生成Al(OH)(OH_2)_5~(+2)、Al_2(OH)_2(OH_2)_8~(+8),后稠合而成Al_6(OH)_(12)(OH_2)_(12)~(+6)的六元环结构,这是氢氧化铝的基本结构单位,后者犹如聚合反应又互相稠合成Al_(54)(OH)_(144)~(+8)·36H_2O,其结构由IR 及X-射线衍射证实。聚合反应的程度影响氢氧化铝的粘度、表面积等性质。时间愈长聚合反应愈充份。从空间障碍观
Aluminum hydroxide is harmless to the human body and is the only vaccine adjuvant recognized by the FDA. The mechanism of action is not yet clear enough. It was simply regarded as an adsorptive effect. However, the properties of surface area, surface charge and morphology are undoubtedly important factors affecting its effect . This article summarizes relevant information in this regard. Al (OH) 2 (OH 2) 5 + (2), Al 2 (OH) 2 (OH 2) 2 and Al 2 (OH 2) (8) (+8) and then fused to form a 6-membered ring structure of Al 6 (OH) 12 (OH 2) 12 (+6), which is the basic structural unit of aluminum hydroxide, It is as if the polymerization is condensed into Al 54 (OH) 144 (+8) 36H 2 O, the structure of which is confirmed by IR and X-ray diffraction. The degree of polymerization affects the viscosity, surface area and other properties of the aluminum hydroxide. The longer the polymerization reaction more fully. Obstacle from the perspective of space