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目的探讨马来酸曲美布汀胶囊联合奥美拉唑治疗反流性食管炎的临床疗效。方法选取2012年1月—2014年5月长埫口镇中心卫生院收治的反流性食管炎患者100例,采用SAS 13.0生成随机数的方法将其分为观察组与对照组,各50例。对照组患者予以奥美拉唑治疗,观察组患者在对照组基础上加用马来酸曲美布汀胶囊治疗。观察两组患者临床疗效、不良反应发生情况及随访半年的复发情况。结果观察组患者总有效率高于对照组,差异有统计学意义(P<0.05);观察组患者不良反应发生率及复发率低于对照组,差异有统计学意义(P<0.05)。结论马来酸曲美布汀胶囊联合奥美拉唑治疗反流性食管炎的临床疗效显著,且不良反应少,复发率低。
Objective To investigate the clinical efficacy of trimebutine maleate capsule combined with omeprazole in the treatment of reflux esophagitis. Methods One hundred patients with reflux esophagitis admitted from January 2012 to May 2014 in Changyuankou Central Hospital were enrolled and randomly divided into observation group and control group with SAS 13.0, 50 cases in each group . Patients in the control group were treated with omeprazole. Patients in the observation group were treated with trimebutine maleate on the basis of the control group. Two groups of patients were observed clinical efficacy, adverse reactions and follow-up of six months of recurrence. Results The total effective rate of the observation group was higher than that of the control group (P <0.05). The adverse reaction rate and recurrence rate of the observation group were lower than that of the control group (P <0.05). Conclusion Trimebutine maleate capsule combined with omeprazole in the treatment of reflux esophagitis clinical efficacy was significant, and adverse reactions, low recurrence rate.