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神经纤毛蛋白-1(Neuropilin-1,NRP-1)属跨膜糖蛋白,作为轴突导向分子(semaphorin,Sema)的受体,参与神经导向的调节,同时作为血管内皮生长因子受体2(vascular endothelial growth factorreceptor 2,VEGFR-2)的共受体表达于血管内皮细胞,参与血管新生的调节。近年已基本阐明NRP-1在神经系统中的作用,其在血管新生方面的研究亦逐渐深入。NRP-1可通过依赖血管内皮生长因子(VEGF)的方式或独立的方式参与肿瘤血管新生调节,同时在肿瘤生长及转移中发挥重要作用。NRP-1生物学特性取决于其独特的分子结构。综述NRP-1结构和生物学特性、与VEGF及其受体的相互作用、对肿瘤血管新生的影响及其在妇科肿瘤中的研究。
Neuropilin-1 (NRP-1) is a transmembrane glycoprotein that acts as a receptor for semaphorin (Sema) and is involved in the regulation of neurotransmission. As a receptor for vascular endothelial growth factor 2 vascular endothelial growth factor receptor 2, VEGFR-2) is expressed in vascular endothelial cells and is involved in the regulation of angiogenesis. In recent years, the role of NRP-1 in the nervous system has been basically clarified, and its research on angiogenesis has also been gradually deepened. NRP-1 can participate in the regulation of tumor angiogenesis through vascular endothelial growth factor (VEGF) -dependent manner or independently, and play an important role in tumor growth and metastasis. The biological properties of NRP-1 depend on its unique molecular structure. This review summarizes the structural and biological properties of NRP-1, its interaction with VEGF and its receptor, its effect on tumor angiogenesis and its role in gynecologic oncology.