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为研究砷氟联合染毒对大鼠血中乙酰胆碱脂酶（ＡｃｈＥ）活性的交互影响，以二因子析因方差设计方法用体重１００±５ｇ的Ｗｉｓｔａｒ系雄性大鼠通过自由饮水染毒三氧化二砷（Ａｓ２Ｏ３）和氟化钠（ＮａＦ），６个月时采大鼠尾部全血，用ＤＴＮＢ法测定其ＡｃｈＥ的活性，结果显示：砷可显著地抑制ＡｃｈＥ活性（Ｐ＜０．０５），氟对ＡｃｈＥ活性的作用不显著（Ｐ＞０．０５），砷与氟对ＡｃｈＥ活性的影响存在显著的交互作用（Ｐ＜０．０５）。
In order to study the interaction between Arsenic and Fluoride (Arsenic and Fluoride) exposure in rats, Arsenic trioxide (As2O3) was administered to Wistar rats weighing 100 ± 5g by free water ) And sodium fluoride (NaF). Whole rat tail blood was collected at 6 months. The AchE activity was measured by DTNB method. The results showed that arsenic significantly inhibited AchE activity (P <0.05) (P> 0.05). There was a significant interaction between arsenic and fluoride on AchE activity (P <0.05).