Molecular dynamics simulation of site-directed mutagenesis of HIV-1 Tat trans-activator

• 作 者: Yan Cui Lunjiang Ling Runsheng
• 机 构: ChineseAcadSci,ChineseAcadMedSci
• 出 处: 中国科学通报：英文版
• 发表日期: 1999年8期
• 关键词: human IMMUNODEFICIENCY virus type 1 ( HIV-1) molecular dynamics simulation SITE-

The Cys-rich domain, core region and basic domain are highly conserved and very important to the trans-activation activity of HIV-1 Tat trans-activator. The three-dimensional structures of 6 mutants of HIV-1 Tat protein were constructed with the methods o