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大剂量水杨酸疗法能引起肝脏中毒还较少报导。作者最近遇到一20岁患有系统性红斑狼疮的女性病人,在应用大剂量阿司匹林后很快出现肝细胞病变,病人停药恢复后再用阿司匹林又引起肝功能异常,经肝脏活检显示为非特异性肝炎。该病人用药前的肝功能检查全部正常,在首次应用阿司匹林治疗时,剂量为4.8克/天(按105毫克/公斤体重·天计算)。五天后,诉厌食、恶心、腹部不适,耳鸣。检查发现右上腹压痛、无黄疸
Large doses of salicylic acid therapy can cause liver toxicity is also less reported. The authors recently encountered a 20-year-old female patient with systemic lupus erythematosus who developed hepatocellular lesions shortly after high-dose aspirin use. Aspirin again after the patient was discontinued returned to liver function abnormalities and was non-specific by liver biopsy Heterosexual hepatitis. The patient’s liver function tests were all normal before treatment, with a first dose of 4.8 g / day (at 105 mg / kg body weight · day) when aspirin was first administered. Five days later, v. Anorexia, nausea, abdominal discomfort, tinnitus. Examination found that the right upper quadrant tenderness, no jaundice