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[目的]探讨联合检测血清总胆汁酸(TBA)胃泌素-17(G-17)以及胃蛋白酶原(PGⅠ、PGⅡ)在胃癌诊断中的价值。[方法]采用酶联免疫吸附法及放射免疫法测定36例溃疡型胃癌、34例胃溃疡以及35例慢性胃炎患者血清中G-17、PGⅠ、PGⅡ以及血清TBA。[结果]胃癌组G-17水平明显高于慢性胃炎组和胃溃疡组,胃癌组PGⅠ水平明显低于慢性胃炎组,胃癌组血清TBA阳性率明显高于胃溃疡组和慢性胃炎组。[结论]对血清TBA阳性伴有G-17水平明显升高而PGⅠ水平低下的患者作胃镜进行胃癌筛查,可明显提高早期胃癌的诊断率。
[Objective] To explore the value of combined detection of serum total bile acid (TBA) gastrin-17 (G-17) and pepsinogen (PGI, PGII) in the diagnosis of gastric cancer. [Methods] Enzyme-linked immunosorbent assay and radioimmunoassay were used to determine the serum levels of G-17, PGI, PGII and serum TBA in 36 cases of ulcerated gastric cancer, 34 cases of gastric ulcer, and 35 cases of chronic gastritis. [Results] The level of G-17 in gastric cancer group was significantly higher than that in chronic gastritis group and gastric ulcer group. The level of PGI in gastric cancer group was significantly lower than that in chronic gastritis group. The positive rate of serum TBA in gastric cancer group was significantly higher than that in gastric ulcer group and chronic gastritis group. [Conclusion] Gastric cancer screening for patients with serum TBA positive with elevated G-17 levels and low PGI levels can significantly improve the diagnostic rate of early gastric cancer.