H~3-藻酸双酯钠的药物动力学研究

• 作 者: 刘忠敏 姜国华 仪明光 车璟
• 机 构: 北京师范大学分析测试中心,北京师范大学分析测试中心,中国原子能研究院,青岛第三制药厂 北京
• 出 处: 北京师范大学学报(自然科学版)
• 发表日期: 1991年02期
• 关键词: H~3 藻酸双酯钠 药物动力学研究 体内过程 绝对生物利用度 血浆蛋白结合率 大鼠 药物代谢动力学 人血 血药浓度

研究了不同剂量~3H-藻酸双酯钠(PSS)在小鼠及大鼠体内的吸收、分布,排泄及药物代谢动力学参数.无论口服或静注小鼠组织分布较广,12h 以肝、肾最高,脑,脂肪、骨骼较低,大脑、小脑、脑干放射性分布未见明显差异.静注72h 自小鼠尿排泄60%,粪排泄20%.大鼠口服24h 由胆汁排泄15.3%.小鼠及人血血浆蛋白结合率24h 为98%.PSS 0.8%CMC 混悬液口服的绝对生物利用度为75.6%,具有吸收好,分布广,排泄快等特点.

The absorption, distribution, excretion and pharmacokinetic parameters of 3H-alginate diester sodium (PSS) in mice and rats were studied.Whether the orally administered or intravenously injected mice were distributed widely, There was no significant difference in the radioactivity distribution of the brain, fat, bone, brain, cerebellum and brainstem between 60 and 60% intravenous injection and 20% The binding rate of mouse and human plasma protein was 98% in 24 hours, and the oral bioavailability of PSS 0.8% CMC suspension was 75.6%, which showed good absorption, wide distribution and fast excretion.