论文部分内容阅读
目的 研究甲状腺过氧化物酶抗体(TPOAb)阳性的复发性流产(RSA)患者的治疗方法.方法 选取2010年1月-2016年1月TPOAb阳性的复发性流产患者76例为研究对象,随机分为A组:左甲状腺素片治疗组(n=25)、B组:强的松联合阿司匹林治疗组(n=26)和C组:未治疗对照组(n=25).追踪随访所有患者至2017年6月,记录怀孕后活产和流产情况,比较不同治疗方法的临床疗效.结果 随访过程中A组失访1例,B组失访2例.A组妊娠活产率(75.0％)显著高于B组(45.8％)及C组(36.0％)(P＜0.05),而B组与C组相比较差异无统计学意义.结论 左甲状腺素片能提高TPOAb阳性的复发性流产患者的妊娠活产率,但强的松联合阿司匹林则无明显改善.“,”Objective:To investigate the treatment of patients with recurrent spontaneous abortion of thyroid peroxidase antibody (TPOAb) positive.Methods:Select 76 patients with recurrent spontaneous abortion of TPOAb positive as study group,who were randomly divided into 3 groups:group A (n=25) was treated with levothyroxine,group B (n=26) was treated with prednisone combined with aspirin,and group C (n=25) was not treated as control group.All patients were followed up to June 2017,the rate of live birth and miscarriages were evaluated,the effect of different treatment methods were compared.Results:A statistically significant higher rate of live birth was observed in group A (75.0％) than group B (45.8％) and group C (36.0％) (P＜0.05),While group B and group C compared with no significant difference.Conclusion:Levothyroxine can improve the rate of live birth in patients with recurrent spontaneous abortion of TPOAb positive,however,prednisone combined with aspirin had no significant improvement.