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To establish a model of multiple organ dysfunction syndrome in the elderly (MODSE) byintraperitoneal injection of different doses of zymosan,and to compare the multiple organ dysfunction syndrome(MODS) in adult and in the elderly rats.Methods Adult and senile rats,injected with different doses ofzymosan intraperitoneally were examined for the changes in the function and morphology of the vital organs,includingheart,liver,brain,lungs,and kidneys using blood gas and biochemistry analysis and histopathological examinationmethods.Results Compared with the normal controls of the adult and the elderly rats,the blood gas and bloodbiochemistry changed in different degrees in the different dosed zymosan groups.Pathological changes were alsofound in the vital organs including lungs,heart,liver,brain,kidneys,etc in the experimental groups.Under thesame concentrations of zymosan,the reductions in respiratory,cardiac and renal functions in the senile groups weremuch more severe than those in the corresponding adult group.In the similar degree of model duplication,the senilerats had the tendency to die later than the adult rats.Conclusions Zymosan can be used in both elderly and adultrats to induce MODS model,and the best dosage for MODSE was 0.5g/kg injected peritoneally.The model wouldhopefully be used in the study of mechanisms and the therapeutics on MODSE.(J Geriatr Cardiol 2004;1:58-64.)
To establish a model of multiple organ dysfunction syndrome in the elderly (MODSE) byintraperitoneal injection of different doses of zymosan, and to compare the multiple organ dysfunction syndrome (MODS) in adult and in the elderly rats. Methods Adult and senile rats, injected with different doses ofzymosan intraperitoneally were examined for the changes in the function and morphology of the vital organs, includingheart, liver, brain, lungs, and kidneys using blood gas and biochemistry analysis and histopathological examination methods. Results compared with the normal controls of the adult and the elderly rats, the blood gas and bloodbiochemistry changed in different degrees in the different dosed zymosan groups. Pathological changes were alsofound in the vital organs including lungs, heart, liver, brain, kidneys, etc in the experimental groups. Unit of the concentration of zymosan, the reductions in respiratory, cardiac and renal functions in the senile groups weremuch more severe than those in the co rresponding adult group. the similar degree of model duplication, the senilerats had the tendency to die later than the adult rats. Conclusions Zymosan can be used in both elderly and adultrats to induce MODS model, and the best dosage for MODSE was 0.5 g / kg injected peritoneally. The model would not be used in the study of mechanisms and the therapeutics on MODSE. (J Geriatr Cardiol 2004; 1: 58-64.)