论文部分内容阅读
目的探讨腹膜透析对尿毒症患者血清同型半胱氨酸(Hcy)的清除作用及影响因素。方法采用酶转换法检测20例腹膜透析患者血清、24-h尿和24-h腹透液中Hcy、β2微球蛋白、尿素氮和肌酐水平,计算残余肾和腹膜透析Hcy清除率、尿素清除指数和肌酐清除率。结果 20例腹膜透析患者血清和腹膜透析液Hcy浓度分别为(13.03±13.14)μmol/L和(5.57±3.02)μmol/L,两者呈正相关(r=0.608,P<0.01)。24-h腹膜透析对Hcy的清除量亦与血清Hcy浓度呈正相关(r=0.704,P<0.01)。结论腹膜透析对Hcy有一定的清除作用。
Objective To investigate the clearance effect of peritoneal dialysis on serum homocysteine (Hcy) in uremic patients and its influencing factors. Methods Hcy, β2 microglobulin, urea nitrogen and creatinine in 20 peritoneal dialysis patients serum, 24-h urine and 24-h peritoneal dialysis fluid were detected by enzymatic conversion method. Hcy clearance rate, urea clearance Index and creatinine clearance. Results Hcy levels in serum and peritoneal dialysis fluid of patients with peritoneal dialysis were (13.03 ± 13.14) μmol / L and (5.57 ± 3.02) μmol / L, respectively. There was a positive correlation between them (r = 0.608, P <0.01). Hcy clearance by 24-h peritoneal dialysis was also positively correlated with serum Hcy concentration (r = 0.704, P <0.01). Conclusion Peritoneal dialysis Hcy have some scavenging effect.