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雷公藤多甙(GTW)为市售中成药,长期以来用于类风湿关节炎、慢性肝炎和一些皮肤病的治疗。不久前表明本品对雄大鼠,也可能对男子有抗生育作用。才研究在26名轻型银屑病人,用小剂量(20ms/日)GTW治疗,同时观察精子数据、精浆生化、血清激素及生化、血象、尿常规以及有关免疫及遗传指标。结果表明,服药1月后精子密度,特别是活率,明显下降,2月后降至不育水平;连服5～6月除少数人有暂时性上腹不适外,无其他明显副作用,性功能如常。停药二月后精子恢复。服药时精浆中游离左旋肉毒碱明显下降,停药后恢复,提示作用部位之一为附睾。所观察的其他指标均无明显影响。
Tripterygium glycosides (GTW) are commercially available proprietary Chinese medicines that have long been used in the treatment of rheumatoid arthritis, chronic hepatitis and some skin diseases. Not long ago that the product of male rats, may also have anti-fertility effects on men. Only 26 patients with psoriasis were treated with low-dose (20ms / day) GTW while observing sperm data, seminal plasma biochemical, serum hormone and biochemical, hemogram, urine routine and related immune and genetic parameters. The results showed that after taking medicine for 1 month, the sperm density, especially the survival rate, decreased obviously and dropped to the level of infertility after February. Even for 5 to 6 months, except for a few people who had temporary abdominal discomfort, there were no other obvious side effects Function as usual. Sperm withdrawal after withdrawal in February. When taking seminal plasma free L-carnitine decreased significantly, withdrawal after recovery, suggesting that one of the role of site for the epididymis. The other indicators observed had no significant effect.