论文部分内容阅读
目的:通过对围生期不同抗菌药物暴露途径、暴露时间、出生胎龄、窒息程度、母亲围生期感染情况等因素与新生儿重症监护室(NICU)患儿多重耐药细菌感染之间关系的研究,探讨影响围生儿多重耐药细菌感染的危险因素,为控制和预防感染提供科学依据。方法:选取2013年1月1日~12月31日期间入住NICU的924例围生儿,根据围生期不同暴露途径、暴露时间、出生胎龄、窒息程度、母亲围生期感染情况进行病例调查后分组对比研究,将资料进行单因素分析后进入Logistic多因素回归分析。结果:单因素分析发现抗菌药物暴露途径、暴露时间、出生胎龄、窒息程度、母亲围生期感染情况等因素与围生儿发生多重耐药细菌感染有相关性,差异有统计意义(P<0.01);Logistic多因素回归分析发现抗菌药物暴露途径、暴露时间、窒息程度是影响NICU患儿发生多重耐药细菌感染的独立危险因素。结论:切断围生儿抗菌药物暴露途径,减少暴露时间,提高围生儿出生的产科质量对降低NICU患儿多重耐药细菌感染发生率具有重要的意义。
OBJECTIVE: To investigate the relationship between multidrug-resistant bacterial infections in newborn intensive care unit (NICU) and neonatal intensive care unit (NICU) during perinatal period by means of exposure to different antibiotics, exposure time, gestational age, asphyxia and maternal perinatal infection To investigate the risk factors of multi-resistant bacterial infection in perinatal children, and to provide a scientific basis for the control and prevention of infection. Methods: A total of 924 infants admitted to the NICU from January 1 to December 31, 2013 were enrolled in this study. According to different perinatal exposure, exposure time, gestational age at birth, degree of asphyxia and perinatal infection After the investigation group comparison study, the data were univariate analysis into Logistic multivariate regression analysis. Results: Univariate analysis showed that there were significant correlations between antibacterial drug exposure, exposure time, gestational age, asphyxia, mothers’ perinatal infection and multiple drug-resistant bacterial infections in perinatal children (P < 0.01). Logistic multivariate regression analysis showed that exposure of antimicrobial agents, exposure time and degree of asphyxia were independent risk factors for multi-drug resistant bacterial infection in NICU children. Conclusion: It is of great significance to cut off the route of perinatal antibiotic exposure, reduce the exposure time and improve the obstetric quality of perinatal neonates to reduce the incidence of multidrug-resistant bacterial infections in NICU.