Studies on nucleic acid-synthesizing polypeptides ——1. C-Terminal destetrapeptido- and deshexapeptid

• 出 处: Acta Chimica Sinica(English Edition)
• 发表日期: 1988年03期
• 关键词: analogs synthesizing RNase nucleic residue concluded hydrolysis have termini lat

The relationships between the structures and functions of ribonuclease A(RNase A)have already been entensively studied, but most studies were limited to the hydrolytic acti-vity of the exzyme while only a few reports dealt with its synthetic aspect. From theresults of the studies on RNase A by the inhibitor method and by synthesis of a series of sim-pler analogs by previous workers,it was concluded that His_119 residue of RNase A mol-ecule is necessary for its hydrolytic but not for synthetic activities, the synthetic activities ofthe derived products and synthetic analogs were all higher than the hydrolytic activities, but

The relationships between the structures and functions of ribonuclease A (RNase A) have already been ennsively studied, but most studies were limited to the hydrolytic acti-vity of the exzyme while only a few reports dealt with its synthetic aspect. From the results of the studies on RNase A by the inhibitor method and by synthesis of a series of sim-pler analogs by previous workers, it was therefore that His_119 residue of RNase A mol-ecule is necessary for its hydrolytic but not for synthetic activities, the synthetic activities of the derived products and synthetic analogs were all higher than the hydrolytic activities, but