,Relationship of Plasma IL-6 to the Metabolic Measures associated with Insulin Resistance due to Adi

• 作 者: Ryoyu Takeda Yoshihiro Takayama Yuji Ito Takaharu Masunaga Takahiro Zenda Satoshi Asaka Hisanori Oiwake Kimihide Shinozaki Yoshiyu Takeda Isamu Miyamori WU Pingsheng (吴平生)
• 机 构: Department of Internal Medicine, KKR-Hokuriku Hospital, Kanazawa, Japan“,”Fukui Medical University,
• 出 处: 岭南心血管病杂志(英文版)
• 发表日期: 2004年1期
• 关键词: Insulin resistance HOMA-R Interleukin-6 (IL-6) CRP

Objectives To elucidate the relationship of plasma interleukin-6 (IL-6) to the metabolic measures associated with insulin resistance (IR) due to adiposity. Methods For a cross-sectional study, eighty normotensive men with and without obesity were enrolled consecutively in our health examination center. Fasting blood glucose (FBG), fasting plasma immunoreactive insulin (FIRI), HOMA-R (Homeostasis Model Assessment Insulin Resistance Index), plasma lipids (cholesterol, triglyceride, high density lipoprotein cholesterol), cortisol, dehydroepiandrosterone-sulfate (DHEA-S), interleukin-6 and C-reactive protein(CRP) were measured. Results Plasma levels of FIRI, triglyceride (TG), DHEA-S,CRP and HOMA-R were significantly higher in obese group with BMI over 25 than non-obese group,whereas HDL-C was significantly lower in obese group. BMI was positively correlated with FIRI, TG,hsCRP and HOMA-R, whereas negatively with HDLC. BMI was positively correlated with plasma DHEAS levels but not with cortisol. Plasma levels of IL-6 were positively correlated with FIRI, TG, CRP and HOMA-R but in a multiple regression analysis with IL-6, only HOMA-R and TG remained explainable variables. Conclusions Each of commonly used measures of inflammatory reaction, CRP and IL-6, showed a significantly positive correlation with either FIRI or HOMA-R, suggesting associations between subclinical inflammation and obesity as the risk of type 2 diabetes mellitus.