【摘 要】
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OBJECTIVE:To investigate the potential mecha-nism of the vascular remodeling effect and provide additional information about anti-hypertension ac-tivity of Fufang Qima capsule(复方芪麻胶囊,QM).METHODS:Spontaneous hypertensive rats (SHRs)were used to study the u
【机 构】
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Department of Cardiovascular,The Fifth Clinical Medical College of Guangzhou University of rChinese
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OBJECTIVE:To investigate the potential mecha-nism of the vascular remodeling effect and provide additional information about anti-hypertension ac-tivity of Fufang Qima capsule(复方芪麻胶囊,QM).METHODS:Spontaneous hypertensive rats (SHRs)were used to study the underlying mechanism of the anti-hypertension activity of QM.In this study,SHRs were randomly divided into 5 groups:model group,Telmisartan group (7.2 mg/kg,p.o.),and three QM groups (0.9298,1.8596,and 3.7192 g/kg,p.o.).Wistar Kyoto rats (WKY) were used as normal control group.Blood pressure (BP),aorta,perivascu-lar adipose tissue (PVAT) histology were investigat-ed to evaluate the effect of QM.Nitric oxide (NO)and endothelial nitric oxide synthase (eNOS) phos-phorylation were measured.Adiponectin (APN) se-cretion,as well as APN signal pathway proteins in-cluding APN,adiponectin receptors (R1 and R2)and adenosine 5\'-monophosphate-activated pro-tein kinase (AMPK) were all analyzed.RESULTS:QM significantly reduced BP and amelio-rated the vascular pathological change,i.e.intima media thicken and collagen fiber hyperplasia.Meanwhile,QM increased concentration of NO and the phosphorylation of eNOS in the aorta.The an-ti-hypertensive and endothelia-protective effect of QM could be attributed to activating APN/AMPK pathway by up-regulating the expression of APN in PVAT and APN Receptor 2,AMPKα and phosphory-lated AMPKα in the aorta.CONCLUSION:The QM alleviation effect mecha-nism for primary hypertension was via modulating the APN/AMPK signal pathway.
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