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某些患者吸入干冷空气(CDA)会激发鼻炎的症状,并伴炎症介质水平增加,鼻灌洗液中有血浆渗漏. 因患者主要反应为流涕,且鼻腺体很大程度上受副交感神经支配,故观察鼻对CDA 的反应评估局部用阿托品的作用。在一双盲随机交叉试验中,给18名志愿者鼻内用阿托品(总量0.5mg)或安慰剂。在CDA 激发前后,对受试者的反应包括:症状得分、组胺浓度、鼻灌洗液中N-α-P-对甲苯磺酰基-L-精氨酸甲酯(TAME)-酯酶活性及渗透压检测结果等进行综合评
Inhalation of dry, cold air (CDA) in some patients triggers the symptoms of rhinitis accompanied by increased levels of inflammatory mediators and plasma leaks in the nasal lavage.The patient’s chief reaction is runny nose, and the nasal glands are largely affected by parasympathetic Nerve innervation, so observe nasal response to CDA to assess the role of topical atropine. Eighteen volunteers received atropine (0.5 mg total) or placebo intranasally in a double-blind randomized crossover study. Responses to subjects before and after CDA challenge included symptom score, histamine concentration, N-alpha-p-toluenesulfonyl-L-arginine methyl ester (TAME) -esterase activity in nasal lavage And osmotic pressure test results and other comprehensive evaluation