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目的 探讨多系统萎缩 (MSA)的神经系统症状、体征和神经影像学表现与诊断的关系。方法 分析 12例MSA患者的症状、体征、影像学表现 ,并按诊断标准诊断。结果 12例中橄榄桥脑小脑萎缩(OPCA) 7例 ,纹状体黑质变性 (SND) 4例 ,特发性直立性低血压 (Shy -Dragersyndrome ,SDS) 1例。 结论 中老年起病隐袭 ,进展缓慢 ,有小脑性共济失调、帕金森综合征、自主神经功能障碍三大症状 ,影像学有脑干、小脑萎缩的直接或间接征象 ,排除其它疾病 ,则可诊断多系统萎缩
Objective To investigate the relationship between neurological symptoms, signs, neuroimaging and diagnosis of multiple system atrophy (MSA). Methods The symptoms, signs and imaging findings of 12 MSA patients were analyzed and diagnosed according to diagnostic criteria. Results In the 12 cases, there were 7 cases of olivopontocerebellar atrophy (OPCA), 4 cases of striatum degeneration (SND) and 1 case of idiopathic orthostatic hypotension (SDS). Conclusion The insidious onset of middle-aged and elderly, slow progress, cerebellar ataxia, Parkinson’s syndrome, autonomic dysfunction three symptoms, imaging brain stem, cerebellar atrophy of the direct or indirect signs of excluding other diseases, then Can diagnose multiple system atrophy