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Objective Here we aimed to investigate the difference in clinical characteristics and outcomesbetween pediatric and adult patients with COVID-19. Methods A total of 333 consecutive patients with laboratory-confirmed SARS-CoV-2 infection treatedin the departments of Internal medicine of Shenzhen Third People's Hospital from January 11th toFebruary 10th, 2020 were included. The data were obtained from electronic medical records. The epidemiological data, clinical characteristics, length of hospital stays, and outcomes of pediatric and adult patients were compared. Results Compared with adult patients, pediatric patients had a shorter time of symptom onset to hospitalization than adults [median time, 1 (IQR, 1.0-1.0) d vs. 3 (IQR, 2.0-6.0) d, P < 0.001], milder or fewer symptoms, less severe chest CT findings. The clinical severity classification of children was less severe than adults. Up to 15th March, the end of the follow-up, 33 (100％) children and 292 (97.3％) adult patients had been discharged from hospital. Only 2 (0.7％) adult patients died, with an overall case mortality of 0.6％. The median length of hospital stay of pediatric patients was shorter than that of adult patients [19 (95％ CI: 16.6-21.4) d vs. 21 (95％ CI: 19.9-22.1) d, P = 0.024].Conclusion Pediatric patients with COVID-19 had milder or less clinical symptoms, less evident pulmonary imaging changes, better prognosis, and shorter length of hospital stay.