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Objective:To appraise the effectiveness of HbA_(1c) and fasting plasma glucose(FPG) on screening diabetes in health check-up.Methods:A total of 1 337 individuals(male 850,female 487),aged 27 to 91 years with HbA_(1c) test were included.Participates with HbA_(1c)≥6.0%or FPG≥6.1 mmol/ L underwent oral glucose tolerance test(OGTT).Diabetes mellitus was diagnosed according to the criteria of WHO in 1999,FPG≥7.0 mmol/L and/or OGTT 2 h-postload plasm glucose(2 h-PG)≥11.1 mmol/L.The sensitivity and specificity of HbA_(1c) thresholds and FPG or combination test on screening of diabetes were analyzed.Results:A total of 842 subjects had HbA_(1c)<6.0%,in which 32 had isolated FPG≥6.1 mmol/L,of 495 had HbA_(1c)≥6.0%.Subjects with HbA_(1c)≥6.0% had significant increased disorder indexes than those with HbA_(1c)<6.0%.527 subjects who had HbA_(1c)≥6.0%or FPG≥6.1 mmol/L underwent OGTT.A total of 234 subjects were newly diagnosed diabetes,including 123(123/234,52.56%) with FPG≥7.0 mmol/L,and 111 subjects(111/234, 47.43%) with isolated 2 h-PG≥11.1 mmol/L.Among 234 new diabetes,91.88%(215 subjects) had HbA_(1c)≥6.3%,and 77.40%(181 subjects) had HbA_(1c)≥6.5%.HbA_(1c)≥6.3%combined FPG≥7.0 mmol/L increased the positive rate of newly diagnosed diabetes from 91.88%to 96.58%. Conclusions:HbA_(1c) is a practical and convenient tool for screening undiagnosed diabetes in routine health check-up of a large population.Combined use of HbA_(1c)≥6.3%and/or FPG≥7.0 mmol/L is efficient for early detection of diabetes.
Objective: To appraise the effectiveness of HbA_ (1c) and fasting plasma glucose (FPG) on screening diabetes in health check-up. Methods: A total of 1 337 individuals (male 850, female 487), aged 27 to 91 years with HbA_ (1c) test were included. Participates with HbA_ (1c) ≥ 6.0% or FPG ≥ 6.1 mmol / L underwent oral glucose tolerance test (OGTT). Diabetes mellitus was diagnosed according to the criteria of WHO in 1999, FPG ≥ 7.0 mmol / L and / or OGTT 2 h-postload plasm glucose (2 h-PG) ≧ 11.1 mmol / L. Sensitivity and specificity of HbA_ (1c) thresholds and FPG or combination test on screening of diabetes were analyzed. Results: A total of 842 subjects had HbA_ (1c) <6.0% in which 32 had isolated FPG ≥ 6.1 mmol / L, of 495 had HbA_ (1c) ≥ 6.0%. Subjects with HbA_ (1c) ≥ 6.0% had significant increased disorder indexes than those with or without HbA_ (1c) <6.0% .527 subjects who had HbA_ (1c) ≥6.0% or FPG ≥6.1 mmol / L underwent OGTT.A total of 234 subjects were newly diagnosed diabetes, including 123 (123/234, 52.56% with FPG ≥ 7.0 m mol / L, and 111 subjects (111/234, 47.43%) with isolated 2 h-PG≥11.1 mmol / L.Among 234 new diabetes, 91.88% (215 subjects) had HbA 1c 6.3%, and 77.40% (181 subjects) had HbA_ (1c) ≥6.5% .HbA_ (1c) ≥6.3% combined FPG ≥7.0 mmol / L increased the positive rate of newly diagnosed diabetes from 91.88% to 96.58%. Conclusions: HbA_ (1c) is a practical and convenient tool for screening undiagnosed diabetes in routine health check-up of a large population. Cbined use of HbA_ (1c)> 6.3% and / or FPG> 7.0 mmol / L is efficient for early detection of diabetes.