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采用鼠单克隆抗体间接免疫荧光技术观察了卡介苗多糖核酸（ＢＣＧ－ＰＳＮ）、重组免疫干扰素（ｒＩＦＮ－ｒ）在体外对膀胱癌患者外周静脉血Ｔ淋巴细胞主要组织相容性复合体（ＭＨＣ）Ⅱ类抗原及白细胞介素－２受体（ＩＬ－２Ｒ）表达的影响。结果表明；两者均能诱导病人Ｔ细胞ＤＲ抗原ＩＬ－２Ｒ的表达（Ｐ＜０．０５），而对正常人Ｔ细胞表达的影响无统计学意义。提示ＢＣＧ和ｒＩＦＮ－ｒ防治膀胱癌的作用可能与其诱导ＤＲ抗原、ＩＬ－２Ｒ的表达有关。
BCG-PSN and rIFN-r were used to detect the expression of major histocompatibility complex (MHC) of peripheral blood T lymphocytes in patients with bladder cancer by indirect immunofluorescence with murine monoclonal antibody ) Class II antigen and interleukin-2 receptor (IL-2R) expression. The results showed that both of them could induce the expression of IL-2R of T-cell DR antigen (P <0.05), but had no effect on the expression of T cell in normal people. Tip BCG and rIFN-r in the prevention and treatment of bladder cancer may be related to its induction of DR antigen, IL-2R expression.