Persistently Upregulated Hippocampal mTOR Signals Mediated by Fecal SCFAs Impair Memory in Male Pups

• 作 者: ZHU Yi Tian LIU Xin Ji LIU Kai
• 机 构: DepartmentofNutritionandFoodHygiene,AnhuiProvincialKeyLaboratoryofPopulationHealthandAristogenics,He
• 出 处: 生物医学与环境科学:英文版
• 发表日期: 2019年5期
• 关键词: Cognitive deficits SULFAMONOMETHOXINE Short-chain fatty acids Mammalian target o
• 基金项目: the National Natural Science Foundation of China[81202209],Key Projects of Natural Science Research in Colleges and Universities of Anhui province[KJ2018A0164,KJ2017A189].

Objective To investigate the molecular mechanisms of the adverse effects of exposure to sulfamonomethoxin(SMM) in pregnancy on the neurobehavioral development of male offspring. Methods Pregnant mice were randomly divided into four groups: control‐(normal