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作者从256例、急慢性白血病患者长芯骨髓活检中得到5例,其骨髓的长度对诊断、论断复发或化疗后证实残余疾病具有决定性的意义。例1是低增生性急性粒性白血病,大部分活检标本示低增生性,只有一深层处有极少量白血病母细胞簇。例2及例3,临床疑为慢粒急变,但周围血及骨髓吸取仍为慢性,在长芯活检中,深层骨髓与近皮质的骨髓图象不同,其中1例近皮质区为典型慢性期图象,另1例示致密纤维化,而深层均为母细胞转化图象。例4为急粒经强化疗,骨髓活检芯的外2/3示严重低增生,而内层1/3有分散残余母细胞簇。例5为急性淋巴母细胞白血病,临床复发,骨髓吸取一次正常,一次不满意,长芯骨髓活检,近皮质区示正常骨髓,而深层
Five of the 256 patients with acute and chronic leukemia were obtained from long core bone marrow biopsy. The length of their bone marrow was of decisive significance for the diagnosis, diagnosis and relapse or for the confirmation of residual disease after chemotherapy. Example 1 is hypo-proliferative acute myeloid leukemia, most biopsy specimens show hypo-proliferative, only a very small amount of leukemia blasts in a deep layer. Cases 2 and 3, the clinical suspicion of chronic obstruction, but the peripheral blood and bone marrow aspiration is still chronic, in the long core biopsy, the deep bone marrow and proximal cortical bone marrow imaging is different, one case of proximal cortex is a typical chronic phase The other cases showed dense fibrosis, while the deeper layers were all blast-transformed images. Example 4 for acute granulomatosis by intensive chemotherapy, bone marrow biopsy core 2/3 showed severe low proliferation, while the inner 1/3 of scattered residual mother cell clusters. Case 5 is acute lymphoblastic leukemia, clinical recurrence, bone marrow suction once normal, once unsatisfactory, long core bone marrow biopsy, near the cortical area showed normal bone marrow, and deep