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应用组织切片革兰染色和免疫组织化学染色等方法，对２４０例有凹空细胞的标本（鳞状细胞乳头状瘤３６例．尖锐湿疣６１例，喉癌８５例，子宫颈鳞癌５８例）进行人乳头状瘤病毒（ＨＰＶ）和细菌Ｌ型检测，比较两者在组织中的检出阳性率、分布及组织病理学表现。结果发现，凹空细胞中ＨＰＶ—Ａｇ检出阳性率（７２．１％）与金葡菌ＣｏｗａｎＩ株Ｌ型－Ａｇ检出阳性率（６５．０％）无显著性差异（Ｐ＞０．０５）；革兰染色有６５．４％的凹空细胞检出Ｌ型菌，ＨＰＶ－Ａｇ与Ｌ型－Ａｇ在组织中的分布和组织病理学表现基本一致。表明细菌Ｌ型与病毒具有相似的病理致病特征。细菌Ｌ型感染是引发上述病变及凹空细胞的重要原因之一。
The tissue sections were stained with Gram stain and immunohistochemical staining, and 240 specimens with hollow cells (36 squamous cell papillomas, 61 condyloma acuminata, 85 laryngeal carcinomas, and 58 cervical squamous cell carcinomas) were used. Human papillomavirus (HPV) and bacterial L-type tests were performed to compare the positive rate, distribution and histopathological features of the two detected in the tissue. The results showed that there was no significant difference between the positive rate of HPV-Ag detection (72.1%) and the positive rate of 65.0% of L-Ag in Staphylococcus aureus (P>0.05). Gram-negative staining detected 65.4% of the hollow cells of L-type bacteria, HPV-Ag and L-Ag distribution in the tissue and histopathological performance is basically consistent. It was shown that the bacterial L-type had similar pathological characteristics to the virus. Bacterial L-type infection is one of the important causes of these lesions and hollow cells.