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本文对中药降脂敏对实验性动脉粥样硬化家兔动脉斑映病理改变的作用及血浆脂蛋白亚组分脂质、脂质过氧化物(LPO)的影响做了实验性研究。结果表明:家兔的主动脉及肺动脉斑块形成后,既使停喂胆固醇也不能使斑块自然消退。而用降脂敏治疗后可以使主动脉及肺动脉斑块减少或消退。同时降脂敏可使血清甘油三酯(TG)含量降至正常水平,有显著性差异(P<0.01)。对TC及LDL-C有降低但无统计学意义。对血清脂质过氧化物(LPO)无影响,推测其对自由基无猝熄作用。
In this paper, experimental studies were conducted on the effect of Chinese traditional medicine Jiangzhi sensitive on the pathological changes of experimental atherosclerotic arterial plaque and the influence of plasma lipoprotein sub-component lipids and lipid peroxides (LPO). The results showed that after plaque formation in the aorta and pulmonary arteries in rabbits, cholesterol was not stopped and the plaques did not disappear spontaneously. Treatment with lipid-lowering sensitivity can reduce or eliminate plaque in the aorta and pulmonary arteries. At the same time, lipid-lowering sensitivity can reduce serum triglyceride (TG) levels to normal levels, with significant differences (P<0.01). There was a decrease in TC and LDL-C but not statistically significant. No effect on serum lipid peroxide (LPO), presumably no quenching effect on free radicals.