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目的对原发于胰腺实性-假乳头状瘤(solid-pseudopapillary neoplasm,SPN)进行临床与病理观察,认识其临床病理特征,诊断与鉴别诊断。方法观察了3例胰腺实性-假乳头状瘤的光镜形态,采用Envi-sion法免疫组化标记AAT、Vimentin、Ki-67、CD10等并结合文献复习其生物学行为。结果光学显微镜下:肿瘤细胞形态大多一致,排列呈实性、片状,或以血管为中心的乳头状排列,免疫组化结果一致:AAT、Vimentin、CD10均阳性,Ki-67<3%。结论胰腺实性-假乳头状瘤诊断要结合临床资料,病理组织学形态以及免疫组化结果,该肿瘤预后较好,但有一定的潜在危险性,随访重要。
Objective To observe the clinical and pathological features of primary pancreatic solid pseudopapillary neoplasm (SPN), and to understand its clinicopathological characteristics, diagnosis and differential diagnosis. Methods The morphology of the pancreatic solid-pseudopapillary tumor was observed. Envi-sion immunohistochemical staining of AAT, Vimentin, Ki-67 and CD10 were performed to review the biological behavior. Results Under the light microscope, most of the tumor cells were in the same shape and arranged in a solid, flaky, or vessel-centered papillary form. The results of immunohistochemistry were consistent: AAT, Vimentin and CD10 were all positive and Ki-67 was less than 3%. Conclusion The diagnosis of pancreatic solid-pseudopapillary tumor should be combined with clinical data, histopathological features and immunohistochemical results. The prognosis is good, but there is a certain potential risk, follow-up is important.