A novel protein-DNA interaction involved with the CpG dinucleotide at -30 upstream is linked to the

• 作 者: JieZHANG JianYU JunGU BaoMeiGA
• 机 构: TheState-keyLaboratoryforOncogenesandRelatedGenes
• 出 处: 细胞研究：英文版
• 发表日期: 2004年4期
• 关键词: 二核苷酸 甲基化 转录 基因沉默 蛋白质 脱氧核糖核酸 DNA MAGE-A1 MAGE-A1 DNA methylation transcriptiona
• 基金项目: 国家高技术研究发展计划(863计划)，国家重点基础研究发展计划(973计划)，Science Foundation of Shanghai Municipal Government

To understand the DNA-methylation mediated gene silencing mechanisms, we analyzed in cell culture of the promoter function of the MAGE-A1 gene, which is frequently demethylated and over-expressed in human hepatocellular carcinoma. We have established the