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目的:探讨原发性肝癌患者血清基质金属蛋白酶-9(MMP-9)的水平变化及意义。方法:应用酶联免疫吸附法检测70例原发性肝癌患者血清中MMP-9的水平。结果:原发性肝癌患者血清MMP-9水平显著高于正常对照组(P<0.05),合并肝炎病毒感染及癌细胞转移患者血清MMP-9水平均显著升高(P<0.05)。结论:血清MMP-9水平变化与原发性肝癌的发生、发展密切相关,测定其在原发性肝癌患者血中的变化,将有助于肝癌的早期诊断和预后判断。
Objective: To investigate the changes and significance of serum matrix metalloproteinase-9 (MMP-9) in patients with primary liver cancer. Methods: Serum levels of MMP-9 in 70 patients with primary liver cancer were detected by enzyme linked immunosorbent assay. Results: Serum MMP-9 levels in patients with primary liver cancer were significantly higher than those in controls (P <0.05). Serum MMP-9 levels in patients with hepatitis B virus infection and cancer metastasis were significantly increased (P <0.05). Conclusion: The change of serum MMP-9 level is closely related to the occurrence and development of primary liver cancer. Determining its change in the blood of patients with primary liver cancer will be helpful for the early diagnosis and prognosis of liver cancer.