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3 蛋白质─聚合物共轭体 重组蛋白因缺乏糖基而使其溶解性和稳定性较差,并且有抗原性,与以聚乙二醇（PEG）为代表的水溶性聚合物通过共价键形成轭合物后,轭合物的性质较之未经修饰的原物质有很大改善,溶解度提高,稳定性增强,生物半衰期延长,毒副作用（免疫原性和过敏反应）降低甚至消除,疗效提高,因此在临床上得到应用。 白细胞介素-2经PEG修饰后的轭合物以适当的剂量和方式给药,可以延长血液中IL-2活性达到最大值的时间,延长循环寿命,减轻免疫原性,提高治疗指数和疗效。PEG-天冬酰胺酶轭合物的半衰期较之天然酶延长了17倍,免疫原性也有所降低,治疗指数得以提高。用PEG修饰,在临床上得到应用的酶还有:SOD（超氧化物歧化酶）、ADA（腺苷脱氨酶）、尿酸酶等,都表现出相似的特性。
3 protein ─ polymer conjugate recombinant protein due to the lack of sugar-based solubility and stability is poor, and antigenicity, and polyethylene glycol (PEG) represented by the water-soluble polymer via a covalent bond The formation of conjugates, the nature of the conjugates than the unmodified substances have greatly improved, increased solubility, increased stability, biological half-life extension, reduce side effects (immunogenicity and allergic reactions) or even eliminate the curative effect Improve, so in clinical application. Interleukin-2 PEG-modified conjugates are administered in appropriate dosages and doses to prolong the maximum time of IL-2 activity in the blood, prolong the life of the blood circulation, reduce the immunogenicity and improve the therapeutic index and efficacy . The half-life of the PEG-asparaginase conjugate was 17-fold longer than that of the native enzyme, the immunogenicity was also reduced, and the therapeutic index was increased. Modified with PEG, the clinical application of enzymes are: SOD (superoxide dismutase), ADA (adenosine deaminase), uricase, etc., have shown similar characteristics.