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目的:评价a-硫辛酸联合前列腺素E1对2型糖尿病合并周围神经病变的治疗效果。方法:将90例糖尿病性周围神经病变患者随机分为2组,治疗组给予a-硫辛酸600mg、前列腺素E110ug治疗2周,对照组每天给予前列腺素E110ug治疗2周,观察治疗前后症状和神经电生理的变化。结果:治疗2周后,治疗组有效率为86.9%,对照组有效率为68.2%,差异有统计学意义(P<0.01),2组神经传导速度在治疗后均有不同程度改善,其中治疗组提高更为明显,均有统计学意义(P<0.05)。结论:a-硫辛酸联合前列腺素E1治疗糖尿病合并周围神经病变安全有效。
Objective: To evaluate the therapeutic effect of a-lipoic acid combined with prostaglandin E1 on type 2 diabetic patients with peripheral neuropathy. Methods: Ninety patients with diabetic peripheral neuropathy were randomly divided into two groups. The treatment group received a-lipoic acid 600 mg, prostaglandin E1 10ug for 2 weeks, and the control group received prostaglandin E1 10ug daily for 2 weeks. The symptoms and nerves Electrophysiological changes. Results: After 2 weeks of treatment, the effective rate of the treatment group was 86.9% and that of the control group was 68.2%, the difference was statistically significant (P <0.01). The nerve conduction velocity of the two groups improved to some extent after treatment, of which the treatment Group increased more obvious, both statistically significant (P <0.05). Conclusion: Alpha-lipoic acid combined with prostaglandin E1 in the treatment of diabetic patients with peripheral neuropathy is safe and effective.