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目的:对胃食管反流病患者的焦虑抑郁状态进行研究,并探讨其对治疗的影响。方法:以200例胃食管反流病患者(含非糜烂性反流病患者140例以及反流性食管炎患者60例)为治疗组,以健康受试者350例作为对照组。治疗组用埃索美拉唑40mg/d治疗14天。收集两组的匹茨堡睡眠质量指数表(PSQI)、反流性疾病问卷(RDQ)和综合医院焦虑抑郁量表(HADS),并进行统计学分析。结果:和对照组相比,治疗组患者的睡眠问题发生率及焦虑抑郁状态明显升高(P<0.05);患者的焦虑抑郁状态和症状的严重情况呈正相关;焦虑抑郁状态会对质子泵抑制剂(PPI)的治疗效果产生影响。结论:患者的焦虑抑郁状态和症状的程度呈正相关,焦虑抑郁状态会对质子泵抑制剂(PPI)的治疗效果产生影响。
OBJECTIVE: To study the anxiety and depression status of patients with gastroesophageal reflux disease and to explore its impact on the treatment. Methods: 200 cases of gastroesophageal reflux disease patients (including non-erosive reflux disease in 140 patients and 60 patients with reflux esophagitis) as the treatment group, 350 healthy subjects as a control group. The treatment group with esomeprazole 40mg / d for 14 days. The Pittsburgh Sleep Quality Index (PSQI), Reflux Disease Questionnaire (RDQ) and General Hospital Anxiety Depression Scale (HADS) were collected and analyzed statistically. Results: Compared with the control group, the incidence of sleep problems and anxiety and depression in the treatment group were significantly increased (P <0.05). The anxiety and depression status of the treatment group was positively correlated with the severity of the symptoms. The anxiety and depression status inhibited the proton pump (PPI) treatment effect. Conclusions: There is a positive correlation between the anxiety and depression status of patients and the degree of symptoms. The anxiety and depression status may affect the therapeutic effect of proton pump inhibitor (PPI).