HA-1A单克隆抗体治疗革兰氏阴性菌血症的费用-效果——一种新治疗药物的经济评价

• 作 者: Schulman KA 朱雪奇 邢觉华
• 出 处: 国外医学(卫生经济分册)
• 发表日期: 1992年03期
• 关键词: 革兰氏阴性菌 HA-1A 单克隆抗体治疗 血症 经济评价 敏感性分析 病人数 对照试验 败血症 变量

本文利用医学文献中报道的临床效果资料,用随机、双盲、对照试验进行费用-效果分析,来评价HA-1A单克隆抗体治疗革兰氏阴性菌血症的费用-效果。文章介绍了当临床或经济变量未知时,采用模型方法来确定HA-1A治疗可能的费用-效果比,并对模型进行了严格的敏感性分析。作者认为在发展一种新药的早期做出经济评价,可指导该药在临床上的有效使用。

In this paper, the cost-effectiveness of HA-1A monoclonal antibody in the treatment of Gram-negative bacteremia was evaluated using cost-effectiveness analyzes in clinical literature reported in the medical literature using randomized, double-blind, controlled trials. The article describes a model approach to determine the likely cost-benefit ratio of HA-1A therapy when clinical or economic variables are unknown, and conducts rigorous sensitivity analyzes of the model. The author believes that in the early development of a new drug to make economic evaluation, can guide the effective use of the drug in the clinic.