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为了探讨唾液酸化LewisX和P16在大肠癌表达及其与肿瘤发生发展、浸润转移和预后的关系 ,应用免疫组化微波 LSAB法检测 90例大肠癌唾液酸化LewisX和P16蛋白的表达状况。结果显示 ,大肠癌组织唾液酸化LewisX和P16表达阳性率分别为92 2 %和 4 2 2 % ,唾液酸化LewisX高表达和P16低表达与大肠癌转移和预后有关。提示联合检测唾液酸化LewisX和P16更有助于判断大肠癌恶性程度、预测生物学行为和评估患者预后
In order to investigate the expression of sialyl Lewis X and P16 in colorectal carcinoma and their relationship with tumorigenesis, invasion, metastasis and prognosis, immunohistochemical LSAB method was used to detect the expression of sialyl LewisX and P16 protein in 90 colorectal carcinomas. The results showed that the positive rates of sialyl Lewis X and P16 in colorectal cancer tissues were 92 2% and 42 2%, respectively. The high expression of sialyl LewisX and the low expression of P16 were related to the metastasis and prognosis of colorectal cancer. These results suggest that combined detection of sialyl Lewis X and P16 may be helpful in judging the malignant degree of colorectal cancer, predicting the biological behavior and assessing the prognosis