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本研究用酶联亲和组化法检测４１例（男３５例、女６例）有临床随访资料的原发性小肝癌（ＳＨＣＣ）患者的肝癌组织及癌旁肝组织中雌激素受体（ＥＲ）、孕激素受体（ＰＲ）的分布情况。结果表明癌组织ＥＲ、ＰＲ显色强度明显低于癌周肝组织（Ｐ＜０．０１）。ＰＲ、ＥＲ的阳性率与癌组织分化程度无相关性，但与患者存活时间有明显关系，存活时间较长组ＥＲ、ＰＲ的阳性率较高（Ｐ＜０．０５）。本结果为探索用内分泌抗激素治疗肝细胞癌提供一定的观察依据。
In this study, enzyme-linked affinity immunohistochemistry was used to detect estrogen receptors in hepatocellular carcinoma (HCC) and paracancerous liver tissues of 41 primary (SHCC) patients with clinical follow-up data (41 males and 6 females). ER), Progesterone receptor (PR) distribution. The results showed that the color intensity of ER and PR in cancer tissue was significantly lower than that in the liver tissue around the cancer (P<0.01). There was no correlation between the positive rate of PR and ER and the degree of differentiation of cancer tissue, but there was a significant relationship with the survival time of patients. The positive rate of ER and PR in the longer survival time group was higher (P<0.05). This study provides a basis for exploring the use of endocrine antihormones in the treatment of hepatocellular carcinoma.