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合成了40个卟啉环上具有不同取代基的单铁、锰卟啉和u-氧桥连双铁、锰卟啉，研究了这些金属卟啉模拟细胞色素P－450单充氧酶在温和条件下催化环己烷羟基化的反应．首次用线性自由能关系对金属卟啉仿生催化反应和金属卟啉自氧化反应进行相关分析，获得一些新的结果和规律．在此基础上，对金属卟啉仿生催化反应的可能机理进行了探讨．
We synthesized 40 iron, manganese porphyrins and u-oxo bridged bis-iron and manganese porphyrins with different substituents on the porphyrin ring. The effects of these metalloporphyrins on cytochrome P-450 monooxygenase Under the conditions of catalytic cyclohexane hydroxylation reaction. For the first time, the relationship between the biomimetic catalytic reaction of metalloporphyrin and the autoxidation of metalloporphyrin was analyzed by linear free energy relationship, and some new results and rules were obtained. On this basis, the possible mechanism of biomimetic catalytic reaction of metalloporphyrin was discussed.