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目的观察异丙酚对全身炎症反应综合征(SIRS)患者血前降钙素的影响。方法将60例SIRS患者随机分为两组,异丙酚组(n=30)和咪唑安定组(n=30),监测患者入院当天及入院后第3、5、7天的体温、血常规以及外周血中PCT水平,记录患者的急性生理和慢性健康状况评分(APACHEⅡ),并追踪患者的转归。结果异丙酚组除入院当天外,其余各个时点的PCT水平均明显低于咪唑安定组(P<0.05),两组的PCT水平都呈下降趋势,异丙酚组经治疗第3天后的PCT水平与入院时相比均明显降低(P<0.05),而咪唑安定组经治疗第3天后的PCT水平与入院时相比,差异无显著性。两组患者APACHEⅡ评分、白细胞计数、中性粒细胞比例、体温以及死亡率差异均无显著性。结论异丙酚可有效降低SIRS患者外周血中PCT水平。
Objective To investigate the effect of propofol on blood pre-calcitonin in patients with systemic inflammatory response syndrome (SIRS). Methods Sixty patients with SIRS were randomly divided into two groups: propofol group (n = 30) and midazolam group (n = 30). The body temperature, blood routine As well as PCT levels in peripheral blood. The patients’ acute physiology and chronic health status score (APACHE II) were recorded and the patient’s prognosis was tracked. Results In the propofol group, the PCT levels at all other time points were significantly lower than those in the midazolam group (P <0.05) except for the day of admission, and the PCT levels in both groups showed a decreasing trend. The PCT level in the propofol group after the third day of treatment PCT levels were significantly lower than those at admission (P <0.05), while there was no significant difference in PCT level after 3 days of treatment in the midazolam group. There was no significant difference in APACHEⅡscore, white blood cell count, neutrophil ratio, body temperature and mortality between the two groups. Conclusion Propofol can effectively reduce PCT levels in peripheral blood of SIRS patients.