Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines

• 作 者: Xin Zhai Juan Li Lei He Su Zhe
• 机 构: School of Pharmaceutical Engineering,Shenyang No. 1 Pharmaceutical Factory
• 出 处: 中国化学快报（英文版）
• 发表日期: 2004年期
• 关键词: Phthalazine derivatives Synthesis Cytotoxicity

Eight novel 1,4-disubstituted phthalazines (7-14) were designed and synthesized. The structures of all the synthesizedcompounds were confirmed by IR, 1H NMR,13C NMR, MS and elemental analysis. Their in vitro cytotoxicity against cancercell lines (Bel-7402 and HT-1080) were evaluated by standard MTT assay. Among them, compounds 9 and 11 exhibited more potentcytotoxicity than cisplatin.