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目的 分析橄榄桥脑小脑萎缩 (OPCA)的临床表现、CT及MRI特征 ,以利早期诊断。方法 对 5 1例OPCA病人的临床表现及其 18例头颅CT和 33例头颅MRI特征进行回顾性分析。结果 OPCA男性多于女性 ,平均年龄 45 .5岁 ,平均病程 12年。其临床表现多种多样 ,以小脑症状、植物神经症状及锥体外系症状多见 ,头颅MRI比头颅CT效果好 ,以小脑和脑干萎缩为主 ,大脑皮质萎缩轻。结论 成年人出现小脑性共济失调、植物神经功能紊乱和锥体外系症状 ,应高度怀疑OPCA ,且MRI有助于早期诊断。
Objective To analyze the clinical manifestations, CT and MRI features of olivopontocerebellar atrophy (OPCA) in order to facilitate early diagnosis. Methods The clinical manifestations of 51 OPCA patients and their features of 18 cases of skull CT and 33 cases of skull MRI were analyzed retrospectively. Results There were more males than females with an average age of 45.5 years and a mean duration of 12 years. The clinical manifestations varied, with cerebellar symptoms, autonomic symptoms and extrapyramidal symptoms more common, cranial MRI better than the cranial CT to cerebellar and brain stem atrophy, cortical atrophy. Conclusion Adult patients with cerebellar ataxia, autonomic dysfunction and extrapyramidal symptoms should be highly suspected OPCA, and MRI can help early diagnosis.