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目的探讨术前口服非那雄胺对绿激光前列腺气化术(PVP)气化效率的影响。方法中重度前列腺增生患者150例,随机分成三组:A组术前不予口服非那雄胺,直接行PVP术;B组术前口服非那雄胺2～4周,再行PVP术;C组术前口服非那雄胺6个月以上,再行PVP术。比较三组患者的手术时间、术中出血量和激光气化效率。结果 A、B、C三组患者术中出血量分别为(43.5±15.1)、(35.7±13.4)和(32.6±11.3)ml;手术时间分别为(108.7±31.2)、(90.5±30.3)和(98.2±29.8)min;激光气化效率分别为(7.4±0.8)、(6.9±0.6)和(7.2±0.7)KJ/cm3。B、C两组患者的术中出血量较A组明显减少(P<0.05);而B、C两组比较,术中出血量差异无显著意义(P>0.05)。与A组比较,B组患者的手术时间明显减少(P<0.05),激光气化效率显著提高(P<0.05);但A、C两组比较,以及B、C两组比较,手术时间和激光气化效率差异无显著意义(P>0.05)。结论术前口服非那雄胺2～4周或6个月以上均可有效减少PVP术中出血量,术前短时间(2～4周)口服非那雄胺可提高PVP术激光气化效率,缩短手术时间,但术前长期(6个月以上)口服非那雄胺对此则无明显帮助。
Objective To investigate the effect of preoperative finasteride on the vaporization efficiency of green laser prostate gasification (PVP). Methods One hundred and fifty patients with severe benign prostatic hyperplasia were randomly divided into three groups: group A was given preoperative finasteride without PVS; Group B received finasteride for 2 to 4 weeks before PVP; Group C preoperative finasteride over 6 months, then PVP surgery. The operation time, intraoperative blood loss and laser vaporization efficiency were compared between the three groups. Results The blood loss in the three groups was (43.5 ± 15.1), (35.7 ± 13.4) and (32.6 ± 11.3) ml, respectively. The operative time was 108.7 ± 31.2 and 90.5 ± 30.3, respectively (98.2 ± 29.8) min, and the laser gasification efficiencies were (7.4 ± 0.8), (6.9 ± 0.6) and (7.2 ± 0.7) KJ / cm3, respectively. The blood loss in group B and C was significantly lower than that in group A (P <0.05), while there was no significant difference in the amount of bleeding between groups B and C (P> 0.05). Compared with group A, the operation time of group B was significantly reduced (P <0.05) and the efficiency of laser vaporization was significantly increased (P <0.05). However, compared with group A and C and group B and C, the operation time and There was no significant difference in laser vaporization efficiency (P> 0.05). Conclusion Preoperative finasteride 2 to 4 weeks or 6 months or more can effectively reduce the amount of PVP bleeding, short period of time (2 to 4 weeks) before taking finasteride can improve PVP laser vaporization efficiency , Shorten the operation time, but preoperative long-term (6 months) oral finasteride no significant help.